Ebook Principles of Process Research and Chemical Development in the Pharmaceutical Industry, by Oljan Repic
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Principles of Process Research and Chemical Development in the Pharmaceutical Industry, by Oljan Repic
Ebook Principles of Process Research and Chemical Development in the Pharmaceutical Industry, by Oljan Repic
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This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
- Sales Rank: #2859976 in Books
- Published on: 1998-01-05
- Original language: English
- Number of items: 1
- Dimensions: 9.47" h x .63" w x 6.36" l, 1.00 pounds
- Binding: Hardcover
- 240 pages
From the Publisher
This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
From the Back Cover
Without process R&D there would be no modern pharmaceutical industry. Yet, unlike most other areas of chemistry, it is not taught in schools. As a consequence, the only way for chemists to acquire chemical development expertise is through on-the-job training--a process that can last several years. This book helps shorten the learning curve.
Dr. Oljan Repic clearly explains the goals and basic principles of chemical development. He explores the crucial aspects of a new process that must be considered when scaling up a research synthesis to industrial levels. And, with the help of many fascinating case studies and vignettes, he delineates each phase of the development process. Key topics include:
* Qualities of an ideal process
* Techniques for minimizing impurities
* Criteria for cost-effective synthesis of enantiopure compounds by resolutions
* Asymmetric synthesis and the "chiral pool" strategy
* Synthesis for labeling substances with hydrogen or carbon isotopes
* New drug registration requirements
Writing with candor, wit, and an unflagging enthusiasm for his chosen profession, Dr. Repic vividly chronicles the challenges, disappointments, and rewards experienced by the member of a chemical development team responsible for bringing a lifesaving drug to market. This book is an invaluable reference for professionals as well as an important source of guidance and inspiration for young chemists considering entering the field.
Most helpful customer reviews
4 of 4 people found the following review helpful.
A fundamental introductory guidebook
By Dr Oliver James Egan
The book starts by giving the fundamental rundown on all the major points in process development and then moves on to about twenty worked examples taken from industry. It also discusses other essential points such as economy, GMP, and the things that you don't imagine process development to be about, but should. I am relatively new to process development and I find the book very helpful, but I don't know if the book would be very revealing to a more experienced process chemist.
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